Is this pepsin treated collagen?
Q: Is this pepsin treated collagen still MMP-sensitive? Can this collagen be cleaved and form PGP (proline-glycine-proline, tri-peptide)(the collagen-derived chemo-attractant)?
A: The simple answers to these two questions are “Yes”. The collagen molecule in PureCol, Nutragen and VitroCol were prepared from native collagen matrix by pepsin treatment under controlled conditions to remove the non-helical portion, telo-peptides, only and the helical portion is intact. In this case, the enzymatic active sites for MMP (Matrix Metalloproteinase), such as for Mammalian Collagenase Matrix Metalloproteinase 8 (MMP-8), on the molecule was preserved. These pepsin treated collagen products should be behaved as a native intact collagen.
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